| 1. Coating Agents |
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POLYQUID PA-30 can
be mixed together with plasticizers, anti-adhesive
agents, coloring agents, etc. if necessary, and
then can be diluted with purified water to a suitable
viscosity for use. |
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| A.
Plasticizers |
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Generally, a plasticizer
is added to this product in because this product
itself forms a hard and fragile film. The standard
concentration of the plasticizer is 10 to 25 wt
% to the evaporated residue of POLYQUID PA-30
(solids content).
Triacetin, propylene glycol, MACROGOL (40, 1500,
4000, 6000), glycerin, POLYSORBATE 80, etc. are
used as plasticizers. |
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| B.
Anti-adhesive Agents |
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Anti-adhesive agents
are used for preventing preparations from adhering
because adhesion may occur between preparations
in the coating process. Generally, talc is applied
as an anti-adhesive agent. Kaoline, colloidal
silica, etc. can be also applied. POLYQUID PA-30
should not be used together with magnesium stearate
because it may agglutinate copolymer ingredients
in this product. |
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| C. Coloring
Agents |
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Coloring agents are
used for ease of identification. Iron ( )
oxide, iron ()
oxide (yellow color) and titanium oxide are applied
as coloring agents.
Resistance of POLYQUID PA-30 to the 1st fluid1)
end to become worse when the amount of titanium
oxide exceeds 30 wt % to solids content of this
product. |
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Amount of Titanium Oxide added and Results of Disintegration
Test (JPE) |
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| Titanium oxide wt % (solids
content of POLYQUID PA-30) |
0 |
10 |
20 |
30 |
40 |
| The 1st fluid
1) |
Conforming
|
Conforming |
Conforming |
Conforming |
Not Conforming |
|
1) An aqueous solution of sodium chloride
and hydrochloric acid
(disintegration test described in JPE). |
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| 2. Mixing Procedure
for Coating Agents |
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Anti-adhesive agents
and coloring agents cannot be dispersed in water
if they are not rapidly agitated. However, copolymer
ingredients may be separated out from POLYQUID
PA-30 when this product is rapidly agitated. Therefore,
the recommended mixing procedure is as follows: |
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Mix a plasticizer and
purified water at room temperature to uniformly
dissolve. |
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Add anti-adhesive agents
and coloring agents to the mixture, and
then agitate it rapidly using a homogenizer
to uniformly disperse. |
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Add POLYQUID PA-30 to
the mixture while agitating slowly. Agitate
it until mixed uniformly. |
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Pass the mixture through
a filter (gap: approx. 150 µm) if
necessary. Then, a coating agent is obtained.
[Notice: The resulting coating agent should
be agitated at a moderate speed in order
to prevent the ingredients from aggregations
and depositions until it will be used as
a coating agent.] |
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| Precaution against
Mishandling |
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| * |
Determine the optimal agitation
conditions for POLYQUID PA-30 according to the
apparatus applied because copolymer ingredients
may be separated out when it is rapidly agitated. |
| * |
Use this product after confirming
the performance to allow it to exert its expected
performance, because the effects, stability and
safety depend on other agents added, the amount,
formula, direction for use, etc. |
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