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Tablets, granules
and powder medicines were coated using POLYQUID
PA-30 on a small scale. Performance tests of the
coated medicines are shown below. |
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1. Example of
Test 
for Tablet Coating Agent with POLYQUID PA-30 |
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A test result measured
using enteric-soluble coated tablets 1) with this
product according to JPE is shown below. |
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Test Result Measured According to JPE |
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| The
1st fluid 2) |
Conforming |
| The
2st fluid 2)
(disintegration time) |
18.2
min |
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1) Tablets were beforehand
coated with hydroxypropyl methylcellulose (as first
sealing coats).
2) Disintegration test described in JPE. |
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Relationship Between pH and Disintegration Time
(in McIlvain buffer solution) |
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Dissolution Test(in the 2nd fluid,paddle method,
50rpm) |
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2. Example of
Test 
for Tablet Coating Agent with POLYQUID PA-30 |
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A test result measured
using enteric-soluble coated tablets with this
product according to JPE is shown below. |
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Test Result Measured Using the 1st Fluid Described in
JPE |
|
Amount
of Coating Agent
(wt %) |
Disintegration
Test Using the 1st Fluid |
Amount
of Absorption of the 1st Fluid on Tablets (wt
%) |
| 4 |
Conforming |
6.2 |
| 5 |
Conforming |
5.5 |
| 6 |
Conforming |
4.7 |
| 7 |
Conforming |
4.5 |
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| 3. Example of
Test for Coated Granules with POLYQUID PA-30 |
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A test result measured
using enteric-soluble coated granules (extruded
granules) with this product according to JPE is
shown below. |
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Test Result Measured According to JPE |
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| |
Granules
(water content : 4.0 wt %) |
Coated
Granules
(water content : 4.0 wt %) |
The
1st fluid
|
- |
Conforming |
| The
2st fluid (Disintegration time) |
5.5
min |
10.5
min |
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| 4. Example of
Test for Masking Pungency of Powder Medicines |
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Particle size distributions
of coated powder medicines with POLYQUID PA-30
and of uncoated powder medicines are shown below. |
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Particle Size Distribution of Powder Medicines |
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| 5. Testing Methods
(Please click each the following
items to see the testing methods.) |
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for Tablet Coating Agent
for Tablet Coating Agent
